PTPN11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

The human gene PTPN11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene, as dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signal...

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Detalhes bibliográficos
Main Authors: Bard-Chapeau, Emilie A., Li, Shuangwei, Ding, Jin, Zhang, Sharon S., Zhu, Helen H., Princen, Frederic, Fang, Diane D., Han, Tao, Bailly-Maitre, Beatrice, Poli, Valeria, Varki, Nissi M., Wang, Hongyang, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098128/
https://ncbi.nlm.nih.gov/pubmed/21575863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.03.023
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