Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death

The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart f...

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Detaylı Bibliyografya
Asıl Yazarlar: Princen, Frederic, Bard, Emilie, Sheikh, Farah, Zhang, Sharon S., Wang, Jing, Zago, Wagner M., Wu, Dongmei, Trelles, Ramon Diaz, Bailly-Maitre, Beatrice, Kahn, C. Ronald, Chen, Yan, Reed, John C., Tong, Gary G., Mercola, Mark, Chen, Ju, Feng, Gen-Sheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612510/
https://ncbi.nlm.nih.gov/pubmed/19001090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01661-08
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