Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death

The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart f...

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Main Authors: Princen, Frederic, Bard, Emilie, Sheikh, Farah, Zhang, Sharon S., Wang, Jing, Zago, Wagner M., Wu, Dongmei, Trelles, Ramon Diaz, Bailly-Maitre, Beatrice, Kahn, C. Ronald, Chen, Yan, Reed, John C., Tong, Gary G., Mercola, Mark, Chen, Ju, Feng, Gen-Sheng
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612510/
https://ncbi.nlm.nih.gov/pubmed/19001090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01661-08
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