Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc tra...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Jiang, Xin, Guo, Honggang, Wu, Jianguo, He, Qiang, Li, Yiqiao, Wang, Miao, Pan, Hongyang, Li, Wande, Wang, Jinjie, Wang, Qingqing, Shen, Jing, Ke, Yuehai, Zhou, Ren
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258751/
https://ncbi.nlm.nih.gov/pubmed/25193962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.106401
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