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A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also pharmacologically relevant as they are often targeted with higher selectivity than orthosteric sites. However, a comprehensive map of allosteric sites poses experimental challenges because allostery is d...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258684/ https://ncbi.nlm.nih.gov/pubmed/25482377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07306 |
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