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A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also pharmacologically relevant as they are often targeted with higher selectivity than orthosteric sites. However, a comprehensive map of allosteric sites poses experimental challenges because allostery is d...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Boulton, Stephen, Akimoto, Madoka, Selvaratnam, Rajeevan, Bashiri, Amir, Melacini, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258684/
https://ncbi.nlm.nih.gov/pubmed/25482377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07306
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