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pH-Dependent Vesicle Fusion Induced by the Ectodomain of the Human Immunodeficiency Virus Membrane Fusion Protein gp41: Two Kinetically Distinct Processes and Fully-Membrane-Associated gp41 with Predominant β Sheet Fusion Peptide Conformation

The gp41 protein of the Human Immunodeficiency Virus (HIV) catalyzes fusion between HIV and host cell membranes. The ~180-residue ectodomain of gp41 is outside the virion and is the most important gp41 region for membrane fusion. The ectodomain consists of an apolar fusion peptide (FP) region follow...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Ratnayake, Punsisi U., Sackett, Kelly, Nethercott, Matthew J., Weliky, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258546/
https://ncbi.nlm.nih.gov/pubmed/25078440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.07.022
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