Cu,Zn-Superoxide Dismutase without Zn is Folded but Catalytically Inactive

Amyotrophic Lateral Sclerosis has been linked to the gain of aberrant function of superoxide dismutase, Cu,Zn-SOD1 upon protein misfolding. The mechanism of SOD1 misfolding is thought to involve mutations leading to the loss of Zn, followed by protein unfolding, and aggregation. We show that the rem...

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Bibliografske podrobnosti
izdano v:J Mol Biol
Main Authors: Nedd, Sean, Redler, Rachel L., Proctor, Elizabeth A., Dokholyan, Nikolay V., Alexandrova, Anastassia N.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258539/
https://ncbi.nlm.nih.gov/pubmed/25083917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.016
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