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Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase

Aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in Amyotrophic Lateral Sclerosis (ALS). Glutathionylation and phosphorylation of SOD1 is omnipresent in the human body, even in healthy individuals, and has been shown to increase SOD1 dimer dissociation, which is the first step on the...

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Sonraí Bibleagrafaíochta
Main Authors: Proctor, Elizabeth A., Ding, Feng, Dokholyan, Nikolay V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082150/
https://ncbi.nlm.nih.gov/pubmed/21396374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.004
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