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Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase

Aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in Amyotrophic Lateral Sclerosis (ALS). Glutathionylation and phosphorylation of SOD1 is omnipresent in the human body, even in healthy individuals, and has been shown to increase SOD1 dimer dissociation, which is the first step on the...

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Detalhes bibliográficos
Main Authors: Proctor, Elizabeth A., Ding, Feng, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082150/
https://ncbi.nlm.nih.gov/pubmed/21396374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.004
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