Cu,Zn-Superoxide Dismutase without Zn is Folded but Catalytically Inactive

Amyotrophic Lateral Sclerosis has been linked to the gain of aberrant function of superoxide dismutase, Cu,Zn-SOD1 upon protein misfolding. The mechanism of SOD1 misfolding is thought to involve mutations leading to the loss of Zn, followed by protein unfolding, and aggregation. We show that the rem...

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Vydáno v:J Mol Biol
Hlavní autoři: Nedd, Sean, Redler, Rachel L., Proctor, Elizabeth A., Dokholyan, Nikolay V., Alexandrova, Anastassia N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258539/
https://ncbi.nlm.nih.gov/pubmed/25083917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.016
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