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Cu,Zn-Superoxide Dismutase without Zn is Folded but Catalytically Inactive
Amyotrophic Lateral Sclerosis has been linked to the gain of aberrant function of superoxide dismutase, Cu,Zn-SOD1 upon protein misfolding. The mechanism of SOD1 misfolding is thought to involve mutations leading to the loss of Zn, followed by protein unfolding, and aggregation. We show that the rem...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258539/ https://ncbi.nlm.nih.gov/pubmed/25083917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.016 |
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