טוען...

Local unfolding of Cu, Zn Superoxide Dismutase monomer determines the morphology of fibrillar aggregates

Aggregation of Cu, Zn Superoxide Dismutase (SOD1) is often found in Amyotrophic Lateral Sclerosis (ALS) patients. The fibrillar aggregates formed by wildtype and various disease-associated mutants have recently been found to have distinct cores and morphologies. Previous computational and experiment...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Ding, Feng, Furukawa, Yoshiaki, Nukina, Nobuyuki, Dokholyan, Nikolay V.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320695/
https://ncbi.nlm.nih.gov/pubmed/22210350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.029
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