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Local unfolding of Cu, Zn Superoxide Dismutase monomer determines the morphology of fibrillar aggregates
Aggregation of Cu, Zn Superoxide Dismutase (SOD1) is often found in Amyotrophic Lateral Sclerosis (ALS) patients. The fibrillar aggregates formed by wildtype and various disease-associated mutants have recently been found to have distinct cores and morphologies. Previous computational and experiment...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3320695/ https://ncbi.nlm.nih.gov/pubmed/22210350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.029 |
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