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Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation
Misfolding and aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in neuronal death in amyotrophic lateral sclerosis. Each SOD1 monomer binds to 1 copper and 1 zinc ion and maintains its disulfide bond (Cys-57–Cys-146) in the reducing cytoplasm of cell. Mounting experimental evidence su...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2604981/ https://ncbi.nlm.nih.gov/pubmed/19052230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803266105 |
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