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A Primary Role for Disulfide Formation in the Productive Folding of Prokaryotic Cu,Zn-superoxide Dismutase

Enzymatic activation of Cu,Zn-superoxide dismutase (SOD1) requires not only binding of a catalytic copper ion but also formation of an intramolecular disulfide bond. Indeed, the disulfide bond is completely conserved among all species possessing SOD1; however, it remains obscure how disulfide format...

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Detalhes bibliográficos
Main Authors: Sakurai, Yasuyuki, Anzai, Itsuki, Furukawa, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106329/
https://ncbi.nlm.nih.gov/pubmed/24917671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567677
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