Post-Translational Modification by Cysteine Protects Cu/Zn-Superoxide Dismutase From Oxidative Damage

Reactive oxygen species (ROS) are cytotoxic. To remove ROS, cells have developed ROS-specific defense mechanisms, including the enzyme Cu/Zn superoxide dismutase (SOD1), which catalyzes the disproportionation of superoxide anions into molecular oxygen and hydrogen peroxide. Although hydrogen peroxid...

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Autori principali: Auclair, Jared R., Johnson, Joshua L., Liu, Qian, Salisbury, Joseph P., Rotunno, Melissa, Petsko, Gregory A., Ringe, Dagmar, Brown, Robert H., Bosco, Daryl A., Agar, Jeffrey N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859700/
https://ncbi.nlm.nih.gov/pubmed/23927036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4006122
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