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Structural Consequences of Cysteinylation of Cu/Zn-Superoxide Dismutase
The metalloenzyme Cu/Zn-superoxide dismutase (SOD1) catalyzes the reduction of superoxide anions into molecular oxygen and hydrogen peroxide. Hydrogen peroxide can oxidize SOD1, resulting in aberrant protein conformational changes, disruption of SOD1 function, and DNA damage. Cells may have evolved...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859770/ https://ncbi.nlm.nih.gov/pubmed/23919400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400613h |
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