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Structural Consequences of Cysteinylation of Cu/Zn-Superoxide Dismutase

The metalloenzyme Cu/Zn-superoxide dismutase (SOD1) catalyzes the reduction of superoxide anions into molecular oxygen and hydrogen peroxide. Hydrogen peroxide can oxidize SOD1, resulting in aberrant protein conformational changes, disruption of SOD1 function, and DNA damage. Cells may have evolved...

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Detalhes bibliográficos
Main Authors: Auclair, Jared R., Brodkin, Heather R., D'Aquino, J. Alejandro, Petsko, Gregory A., Ringe, Dagmar, Agar, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859770/
https://ncbi.nlm.nih.gov/pubmed/23919400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400613h
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