Identification of a Misfolded Region in Superoxide Dismutase 1 That Is Exposed in Amyotrophic Lateral Sclerosis

Mutations and aberrant post-translational modifications within Cu,Zn-superoxide dismutase (SOD1) cause this otherwise protective enzyme to misfold, leading to amyotrophic lateral sclerosis (ALS). The C4F6 antibody selectively binds misfolded SOD1 in spinal cord tissues from postmortem human ALS case...

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Main Authors: Rotunno, Melissa S., Auclair, Jared R., Maniatis, Stephanie, Shaffer, Scott A., Agar, Jeffrey, Bosco, Daryl A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192504/
https://ncbi.nlm.nih.gov/pubmed/25164820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581801
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