The Neurotensin–HIF-1α–VEGFα Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis

The expression of neurotensin (NT) and its receptor (NTR1) is up-regulated in experimental colitis and inflammatory bowel disease; NT/NTR1 interactions regulate gut inflammation. During active inflammation, metabolic shifts toward hypoxia lead to the activation of hypoxia-inducible factor (HIF)-1, w...

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Dades bibliogràfiques
Publicat a:Am J Pathol
Autors principals: Bakirtzi, Kyriaki, West, Gail, Fiocchi, Claudio, Law, Ivy Ka Man, Iliopoulos, Dimitrios, Pothoulakis, Charalabos
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2014
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258496/
https://ncbi.nlm.nih.gov/pubmed/25307345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.08.015
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