Neurotensin—regulated miR-133α is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis

OBJECTIVE: Neurotensin (NT) mediates colonic inflammation through its receptor neurotensin receptor 1 (NTR1). NT stimulates miR-133α expression in colonic epithelial cells. We investigated the role of miR-133α in NT-associated colonic inflammation in vitro and in vivo. DESIGN: miR-133α and aftiphili...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Law, Ivy Ka Man, Bakirtzi, Kyriaki, Polytarchou, Christos, Oikonomopoulos, Angelos, Hommes, Daniel, Iliopoulos, Dimitrios, Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422787/
https://ncbi.nlm.nih.gov/pubmed/25112884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-307329
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