Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by β-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1

The neuropeptide/hormone neurotensin (NT) mediates intestinal inflammation and cell proliferation by binding of its high affinity receptor, neurotensin receptor-1 (NTR1). NT stimulates IL-8 expression in NCM460 human colonic epithelial cells by both MAP kinase- and NF-κB-dependent pathways. Although...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Law, Ivy Ka Man, Murphy, Jane E., Bakirtzi, Kyriaki, Bunnett, Nigel W., Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340238/
https://ncbi.nlm.nih.gov/pubmed/22416137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.327262
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados