PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and resistance to conventional therapies. Published studies show that the PDA tumor microenvironment (TME) is predominantly infiltrated with immune suppressive cells and signals that if altered, would allow effective i...

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Bibliografiske detaljer
Udgivet i:J Immunother
Main Authors: Soares, Kevin C., Rucki, Agnieszka A., Wu, Annie A., Olino, Kelly, Xiao, Qian, Chai, Yi, Wamwea, Anthony, Bigelow, Elaine, Lutz, Eric, Liu, Linda, Yao, Sheng, Anders, Robert A., Laheru, Daniel, Wolfgang, Christopher L., Edil, Barish H., Schulick, Richard D., Jaffee, Elizabeth M., Zheng, Lei
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258151/
https://ncbi.nlm.nih.gov/pubmed/25415283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000062
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