Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade

Immune checkpoint blockade therapies fail to induce responses in majority of cancer patients; so how to increase the objective response rate becomes an urgent challenge. Here we demonstrate that sufficient T cell infiltration in tumor tissues is a prerequisite for response to PD-L1 blockade. Targeti...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Tang, Haidong, Wang, Yang, Chlewicki, Lukasz K, Zhang, Yuan, Guo, Jingya, Liang, Wei, Wang, Jieyi, Wang, Xiaoxiao, Fu, Yang-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794755/
https://ncbi.nlm.nih.gov/pubmed/26977880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.02.004
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