PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the functions of PD-L1 on dendritic cells (DCs), which highly express PD-L1. We observe that PD-L1 on DC plays a criti...

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Udgivet i:Nat Commun
Main Authors: Peng, Qi, Qiu, Xiangyan, Zhang, Zihan, Zhang, Silin, Zhang, Yuanyuan, Liang, Yong, Guo, Jingya, Peng, Hua, Chen, Mingyi, Fu, Yang-Xin, Tang, Haidong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518441/
https://ncbi.nlm.nih.gov/pubmed/32973173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18570-x
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