PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and resistance to conventional therapies. Published studies show that the PDA tumor microenvironment (TME) is predominantly infiltrated with immune suppressive cells and signals that if altered, would allow effective i...

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Publicado no:J Immunother
Main Authors: Soares, Kevin C., Rucki, Agnieszka A., Wu, Annie A., Olino, Kelly, Xiao, Qian, Chai, Yi, Wamwea, Anthony, Bigelow, Elaine, Lutz, Eric, Liu, Linda, Yao, Sheng, Anders, Robert A., Laheru, Daniel, Wolfgang, Christopher L., Edil, Barish H., Schulick, Richard D., Jaffee, Elizabeth M., Zheng, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258151/
https://ncbi.nlm.nih.gov/pubmed/25415283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000062
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