Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects

AIM: The aim of this study was to assess the safety and tolerability, pharmacokinetics and pharmacodynamics of LY3000328 when administered as single escalating doses to healthy volunteers. METHODS: This was a phase 1, placebo-controlled, dose escalation study with LY3000328 in 21 healthy male volunt...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Payne, Christopher D, Deeg, Mark A, Chan, Melanie, Tan, Lai Hock, LaBell, Elizabeth Smith, Shen, Tong, DeBrota, David J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256622/
https://ncbi.nlm.nih.gov/pubmed/25039273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12470
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