Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm

[Image: see text] Cathepsin S (Cat S) plays an important role in many pathological conditions, including abdominal aortic aneurysm (AAA). Inhibition of Cat S may provide a new treatment for AAA. To date, several classes of Cat S inhibitors have been reported, many of which form covalent interactions...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jadhav, Prabhakar K., Schiffler, Matthew A., Gavardinas, Kostas, Kim, Euibong J., Matthews, Donald P., Staszak, Michael A., Coffey, D. Scott, Shaw, Bruce W., Cassidy, Kenneth C., Brier, Richard A., Zhang, Yuke, Christie, Robert M., Matter, William F., Qing, Keyun, Durbin, Jim D., Wang, Yong, Deng, Gary G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2014
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190634/
https://ncbi.nlm.nih.gov/pubmed/25313327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500283g
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