Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm

[Image: see text] Cathepsin S (Cat S) plays an important role in many pathological conditions, including abdominal aortic aneurysm (AAA). Inhibition of Cat S may provide a new treatment for AAA. To date, several classes of Cat S inhibitors have been reported, many of which form covalent interactions...

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Detalhes bibliográficos
Main Authors: Jadhav, Prabhakar K., Schiffler, Matthew A., Gavardinas, Kostas, Kim, Euibong J., Matthews, Donald P., Staszak, Michael A., Coffey, D. Scott, Shaw, Bruce W., Cassidy, Kenneth C., Brier, Richard A., Zhang, Yuke, Christie, Robert M., Matter, William F., Qing, Keyun, Durbin, Jim D., Wang, Yong, Deng, Gary G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190634/
https://ncbi.nlm.nih.gov/pubmed/25313327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500283g
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