Aminoglycoside Stress Together with the 12S rRNA 1494C>T Mutation Leads to Mitophagy

Aminoglycosides as modifying factors modulated the phenotypic manifestation of mitochondrial rRNA mutations and the incomplete penetrance of hearing loss. In this report, using cybrids harboring the m.1494C>T mutation, we showed that gentamycin aggravated mitochondrial dysfunction in a combinatio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Yu, Jialing, Zheng, Jing, Zhao, Xiaoxu, Liu, Junxia, Mao, Zhuochao, Ling, Yining, Chen, Danni, Chen, Chao, Hui, Lanlan, Cui, Limei, Chen, Ye, Jiang, Pingping, Guan, Min-Xin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256443/
https://ncbi.nlm.nih.gov/pubmed/25474306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114650
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