Aminoglycoside Stress Together with the 12S rRNA 1494C>T Mutation Leads to Mitophagy

Aminoglycosides as modifying factors modulated the phenotypic manifestation of mitochondrial rRNA mutations and the incomplete penetrance of hearing loss. In this report, using cybrids harboring the m.1494C>T mutation, we showed that gentamycin aggravated mitochondrial dysfunction in a combinatio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yu, Jialing, Zheng, Jing, Zhao, Xiaoxu, Liu, Junxia, Mao, Zhuochao, Ling, Yining, Chen, Danni, Chen, Chao, Hui, Lanlan, Cui, Limei, Chen, Ye, Jiang, Pingping, Guan, Min-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256443/
https://ncbi.nlm.nih.gov/pubmed/25474306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114650
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