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Interaction of Aminoglycosides with Human Mitochondrial 12S rRNA Carrying the Deafness-Associated Mutation

The mitochondrial 12S rRNA A1555G mutation is one of the important causes of aminoglycoside-induced and nonsyndromic hearing loss. Here we employed an RNA-directed chemical-modification approach to understanding the pathogenesis of aminoglycoside-induced hearing loss. The patterns of chemical modifi...

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Bibliografiske detaljer
Main Authors: Qian, Yaping, Guan, Min-Xin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772318/
https://ncbi.nlm.nih.gov/pubmed/19687236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00965-08
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