Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity

Boosting NAD(+) biosynthesis with NAD(+) intermediates has been proposed as a strategy for preventing and treating age-associated diseases, including cancer. However, concerns in this area were raised by observations that nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in mammalian NAD(...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Soncini, Debora, Caffa, Irene, Zoppoli, Gabriele, Cea, Michele, Cagnetta, Antonia, Passalacqua, Mario, Mastracci, Luca, Boero, Silvia, Montecucco, Fabrizio, Sociali, Giovanna, Lasigliè, Denise, Damonte, Patrizia, Grozio, Alessia, Mannino, Elena, Poggi, Alessandro, D'Agostino, Vito G., Monacelli, Fiammetta, Provenzani, Alessandro, Odetti, Patrizio, Ballestrero, Alberto, Bruzzone, Santina, Nencioni, Alessio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256351/
https://ncbi.nlm.nih.gov/pubmed/25331943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.594721
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