Conformational Activation of Antithrombin by Heparin Involves an Altered Exosite Interaction with Protease

Heparin allosterically activates antithrombin as an inhibitor of factors Xa and IXa by enhancing the initial Michaelis complex interaction of inhibitor with protease through exosites. Here, we investigate the mechanism of this enhancement by analyzing the effects of alanine mutations of six putative...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Izaguirre, Gonzalo, Aguila, Sonia, Qi, Lixin, Swanson, Richard, Roth, Ryan, Rezaie, Alireza R., Gettins, Peter G. W., Olson, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256340/
https://ncbi.nlm.nih.gov/pubmed/25331949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611707
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