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Engineering Functional Antithrombin Exosites in α(1)-Proteinase Inhibitor That Specifically Promote the Inhibition of Factor Xa and Factor IXa
We have previously shown that residues Tyr-253 and Glu-255 in the serpin antithrombin function as exosites to promote the inhibition of factor Xa and factor IXa when the serpin is conformationally activated by heparin. Here we show that functional exosites can be engineered at homologous positions i...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2615528/ https://ncbi.nlm.nih.gov/pubmed/19010776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807340200 |
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