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Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement
Allosteric activation of antithrombin as a rapid inhibitor of factors IXa and Xa requires binding of a high-affinity heparin pentasaccharide. The currently-accepted mechanism involves removal of a constraint on the antithrombin reactive center loop (RCL) so that the proteinase can simultaneously eng...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821923/ https://ncbi.nlm.nih.gov/pubmed/19818773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.10.005 |
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