The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation

We have previously shown that the L-type calcium channel (LCC) antagonist nilvadipine reduces brain amyloid-β (Aβ) accumulation by affecting both Aβ production and Aβ clearance across the blood-brain barrier (BBB). Nilvadipine consists of a mixture of two enantiomers, (+)-nilvadipine and (−)-nilvadi...

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Vydáno v:J Biol Chem
Hlavní autoři: Paris, Daniel, Ait-Ghezala, Ghania, Bachmeier, Corbin, Laco, Gary, Beaulieu-Abdelahad, David, Lin, Yong, Jin, Chao, Crawford, Fiona, Mullan, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256331/
https://ncbi.nlm.nih.gov/pubmed/25331948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.608091
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