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Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo

Spleen tyrosine kinase (SYK) plays a major role in inflammation and in adaptive immune responses and could therefore contribute to the neuroinflammation observed in various neurodegenerative diseases. Indeed, previously we have reported that SYK also regulates β-amyloid (Aβ) production and hyperphos...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Schweig, Jonas Elias, Yao, Hailan, Coppola, Kyle, Jin, Chao, Crawford, Fiona, Mullan, Michael, Paris, Daniel
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737214/
https://ncbi.nlm.nih.gov/pubmed/31324720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008033
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