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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
BACKGROUND: Aβ deposits represent a neuropathological hallmark of Alzheimer's disease (AD). Both soluble and insoluble Aβ species are considered to be responsible for initiating the pathological cascade that eventually leads to AD. Therefore, the identification of therapeutic approaches that ca...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841120/ https://ncbi.nlm.nih.gov/pubmed/20211007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-17 |
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