Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

BACKGROUND: Aβ deposits represent a neuropathological hallmark of Alzheimer's disease (AD). Both soluble and insoluble Aβ species are considered to be responsible for initiating the pathological cascade that eventually leads to AD. Therefore, the identification of therapeutic approaches that ca...

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Detalhes bibliográficos
Main Authors: Paris, Daniel, Ganey, Nowell J, Laporte, Vincent, Patel, Nikunj S, Beaulieu-Abdelahad, David, Bachmeier, Corbin, March, Amelia, Ait-Ghezala, Ghania, Mullan, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841120/
https://ncbi.nlm.nih.gov/pubmed/20211007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-17
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