Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

BACKGROUND: Aβ deposits represent a neuropathological hallmark of Alzheimer's disease (AD). Both soluble and insoluble Aβ species are considered to be responsible for initiating the pathological cascade that eventually leads to AD. Therefore, the identification of therapeutic approaches that ca...

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Bibliographische Detailangaben
Hauptverfasser: Paris, Daniel, Ganey, Nowell J, Laporte, Vincent, Patel, Nikunj S, Beaulieu-Abdelahad, David, Bachmeier, Corbin, March, Amelia, Ait-Ghezala, Ghania, Mullan, Michael J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841120/
https://ncbi.nlm.nih.gov/pubmed/20211007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-17
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