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Adaptive randomized phase II design for biomarker threshold selection and independent evaluation
BACKGROUND: Frequently a biomarker capable of defining a patient population with enhanced response to an experimental agent is not fully validated with a known threshold at the start of a phase II trial. When such candidate predictive markers are evaluated and/or validated retrospectively, over-accr...
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| Publicado no: | Chin Clin Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255950/ https://ncbi.nlm.nih.gov/pubmed/25485277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2304-3865.2013.12.04 |
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