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Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death

Protein homeostatic regulators have been shown to ameliorate single, loss-of-function protein diseases but not to treat broader animal disease models that may involve cell death. Diseases often trigger protein homeostatic instability that disrupts the delicate balance of normal cellular viability. F...

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Detalhes bibliográficos
Publicado no:Cell Stress Chaperones
Main Authors: Sharma, Sudhish, Mishra, Rachana, Walker, Brandon L., Deshmukh, Savitha, Zampino, Manuela, Patel, Jay, Anamalai, Mani, Simpson, David, Singh, Ishwar S., Kaushal, Shalesh, Kaushal, Sunjay
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255245/
https://ncbi.nlm.nih.gov/pubmed/25300203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-014-0536-1
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