Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32

Hearing loss is often caused by death of the mechanosensory hair cells of the inner ear. Hair cells are susceptible to death caused by aging, noise trauma, and ototoxic drugs, including the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Ototoxic drugs result in permanent hearing...

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Bibliografiske detaljer
Main Authors: Francis, S P, Kramarenko, I I, Brandon, C S, Lee, F-S, Baker, T G, Cunningham, L L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181421/
https://ncbi.nlm.nih.gov/pubmed/21866174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.76
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