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Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32

Hearing loss is often caused by death of the mechanosensory hair cells of the inner ear. Hair cells are susceptible to death caused by aging, noise trauma, and ototoxic drugs, including the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Ototoxic drugs result in permanent hearing...

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Hlavní autoři: Francis, S P, Kramarenko, I I, Brandon, C S, Lee, F-S, Baker, T G, Cunningham, L L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181421/
https://ncbi.nlm.nih.gov/pubmed/21866174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.76
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