Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension

Excess superoxide has been implicated in pulmonary hypertension (PH). We previously found lung overexpression of the antioxidant extracellular superoxide dismutase (EC-SOD) attenuates PH and pulmonary artery (PA) remodeling. Although comprising a small fraction of total SOD activity in most tissues,...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Nozik-Grayck, Eva, Woods, Crystal, Taylor, Joann M., Benninger, Richard K. P., Johnson, Richard D., Villegas, Leah R., Stenmark, Kurt R., Harrison, David G., Majka, Susan M., Irwin, David, Farrow, Kathryn N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254965/
https://ncbi.nlm.nih.gov/pubmed/25326578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00096.2014
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