Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages

A human single nucleotide polymorphism (SNP) in the matrix-binding domain of extracellular superoxide dismutase (EC-SOD), with arginine to glycine substitution at position 213 (R213G), redistributes EC-SOD from the matrix into extracellular fluids. We reported that, following bleomycin (bleo), knock...

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Udgivet i:FASEB J
Main Authors: Allawzi, Ayed, McDermott, Ivy, Delaney, Cassidy, Nguyen, Kianna, Banimostafa, Laith, Trumpie, Ashley, Hernandez-Lagunas, Laura, Riemondy, Kent, Gillen, Austin, Hesselberth, Jay, El Kasmi, Karim, Sucharov, Carmen C., Janssen, William J., Stenmark, Kurt, Bowler, Russell, Nozik-Grayck, Eva
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894081/
https://ncbi.nlm.nih.gov/pubmed/31560857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901038RR
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