Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) worsens clinical outcomes in former preterm infants with bronchopulmonary dysplasia (BPD). Oxidant stress disrupts alveolar and vascular development in models of BPD. Bleomycin causes oxidative stress and induces BPD and PAH in neonatal rats. Disrupt...

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Publicado no:Pediatr Res
Main Authors: Delaney, Cassidy, Wright, Rachel H., Tang, Jen-Ruey, Woods, Crystal, Villegas, Leah, Sherlock, Laurie, Savani, Rashmin C., Abman, Steven H., Nozik-Grayck, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689645/
https://ncbi.nlm.nih.gov/pubmed/26322414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2015.166
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