Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) worsens clinical outcomes in former preterm infants with bronchopulmonary dysplasia (BPD). Oxidant stress disrupts alveolar and vascular development in models of BPD. Bleomycin causes oxidative stress and induces BPD and PAH in neonatal rats. Disrupt...

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Publicat a:Pediatr Res
Autors principals: Delaney, Cassidy, Wright, Rachel H., Tang, Jen-Ruey, Woods, Crystal, Villegas, Leah, Sherlock, Laurie, Savani, Rashmin C., Abman, Steven H., Nozik-Grayck, Eva
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689645/
https://ncbi.nlm.nih.gov/pubmed/26322414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2015.166
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