A Common Polymorphism in EC-SOD Affects Cardiopulmonary Disease Risk by Altering Protein Distribution

BACKGROUND: The enzyme extracellular superoxide dismutase (EC-SOD; SOD3) is a major antioxidant defense in lung and vasculature. A nonsynonomous single nucleotide polymorphism (SNP) in EC-SOD (rs1799895) leads to an arginine to glycine (Arg->Gly) amino acid substitution at position 213 (R213G) in...

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Bibliographic Details
Published in:Circ Cardiovasc Genet
Main Authors: Hartney, John M., Stidham, Timothy, Goldstrohm, David A., Oberley-Deegan, Rebecca E., Weaver, Michael R., Valnickova-Hansen, Zuzana, Scavenius, Carsten, Benninger, Richard K.P., Leahy, Katelyn F., Johnson, Richard, Gally, Fabienne, Kosmider, Beata, Zimmermann, Angela K., Enghild, Jan J., Nozik-Grayck, Eva, Bowler, Russell P.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270938/
https://ncbi.nlm.nih.gov/pubmed/25085920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000504
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