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The high concentration of Arg(213)→Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities
The C-terminal region of EC-SOD (extracellular superoxide dismutase) mediates the binding to both heparin/heparan sulphate and type I collagen. A mutation (Arg(213)→Gly; R213G) within this extracellular matrix-binding region has recently been implicated in the development of heart disease. This rela...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Portland Press Ltd.
2005
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134713/ https://ncbi.nlm.nih.gov/pubmed/15362977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041218 |
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