The high concentration of Arg(213)→Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities

The C-terminal region of EC-SOD (extracellular superoxide dismutase) mediates the binding to both heparin/heparan sulphate and type I collagen. A mutation (Arg(213)→Gly; R213G) within this extracellular matrix-binding region has recently been implicated in the development of heart disease. This rela...

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Detalhes bibliográficos
Main Authors: Petersen, Steen V., Olsen, Dorte Aa., Kenney, John M., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Crapo, James D., Enghild, Jan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134713/
https://ncbi.nlm.nih.gov/pubmed/15362977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041218
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