FOXO transcription factors support oxidative stress resistance in human chondrocytes

OBJECTIVES: A major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box class O (FOXO) transcription factor axis. Previously, we observed that FOXO factors are dysregulated in aged and OA cartilage. The objective of this study was to investigate the impact of d...

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Bibliografiska uppgifter
I publikationen:Arthritis Rheumatol
Huvudupphovsmän: Akasaki, Yukio, Alvarez-Garcia, Oscar, Saito, Masahiko, Caramés, Beatriz, Iwamoto, Yukihide, Lotz, Martin K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254812/
https://ncbi.nlm.nih.gov/pubmed/25186470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38868
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