FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK

Forkhead transcription factors of the FOXO class are negatively regulated by PKB/c-Akt in response to insulin/IGF signalling, and are involved in regulating cell cycle progression and cell death. Here we show that, in contrast to insulin signalling, low levels of oxidative stress generated by treatm...

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Autori principali: Essers, Marieke A G, Weijzen, Sanne, de Vries-Smits, Alida M M, Saarloos, Ingrid, de Ruiter, Nancy D, Bos, Johannes L, Burgering, Boudewijn M T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2004
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC535088/
https://ncbi.nlm.nih.gov/pubmed/15538382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600476
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