Wordt geladen...
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
The progression of many solid tumors is driven by de-regulation of multiple common pathways, particularly Rb, PI (3) K/Akt and p53. Prior studies identified TopBP1as a key mediator for the oncogenic gain-of-function activities of mutant p53 (mutp53) in cancer. In Akt-hyperactive cancer, TopBP1 forms...
Bewaard in:
| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2014
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254804/ https://ncbi.nlm.nih.gov/pubmed/25400145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6476 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|