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Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
The progression of many solid tumors is driven by de-regulation of multiple common pathways, particularly Rb, PI (3) K/Akt and p53. Prior studies identified TopBP1as a key mediator for the oncogenic gain-of-function activities of mutant p53 (mutp53) in cancer. In Akt-hyperactive cancer, TopBP1 forms...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254804/ https://ncbi.nlm.nih.gov/pubmed/25400145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6476 |
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